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but no such change occurred in the abacavir arm. No differences in CD4 cell count, viral load, or blood lipids were observed between the two arms at week 104. A total of ten serious adverse events were reported, including four cases of the abacavir hypersensitivity reaction in patients who switched from AZT or d4T after week 24. The investigators comment that “overall, patients randomised to abacavir had greater fat teen sex recovery of limb fat mass compared with fat teen sex those remaining on thymidine analogues. However, there was no difference in [visceral adipose tissue], buffalo hump, fat teen sex self-assessed lipodystrophy,” or elevated blood lipids. They add that “this demonstrates that lipoatrophy can be abrogated using this switching strategy, but the overall features of lipodystrophy syndrome may not. The study findings further support a causal role for thymidine analogues in the pathogenesis of the lipodystrophy syndrome.”
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